Interspecies transcriptomic comparison identifies a potential porto-sinusoidal vascular disorder rat model suitable for in vivo drug testing.

Genís Campreciós Marina Vilaseca Dinesh Mani Tripathi Carla Montironi Alba Díaz Daniel Aguilar Héctor García-Calderó Rosa Montañés Aina Anton Virginia Hernández-Gea Joan Carles García-Pagán

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

The Selfox rat model faithfully reproduces the main alterations described in PSVD. Its use as a preclinical model for drug testing in progressing PSVD can be a significant step forward towards the development of new therapeutic targets for this rare condition.

Keyphrases

adverse drug
single cell
cell therapy
drug induced
rna seq
gene expression
emergency department
risk assessment
human health
mesenchymal stem cells
electronic health record