A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes.
Zhendong ChenMax TaubertChunli ChenJana BolandQian DongMuhammad BilalCharalambos DokosBertil WachallManfred WargenauBernhard ScheidelMartin H J WiesenElke SchaeffelerRoman TremmelMatthias SchwabUwe FuhrPublished in: Drugs in R&D (2024)
The current work is expected to facilitate the future pharmacokinetic/pharmacodynamic development of noscapine. This study was registered prior to starting at "Deutsches Register Klinischer Studien" under registration no. DRKS00017760.
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