Glut5 Knockdown in the Nucleus Tractus Solitarii Alleviates Fructose-Induced Hypertension in Rats.

Chieh-Jen WuPei-Wen ChengMing-Hsiang KungChiu-Yi HoJun-Yen PanChing-Jiunn Tseng Hsin-Hung Chen

Published in: The Journal of nutrition (2021)

Fructose induced reactive oxygen species generation in the NTS of rats through GLUT5 and receptor for advanced glycation end products (RAGE) signaling, thus impairing the AKT-nNOS-NO signaling pathway and ultimately causing hypertension.

Keyphrases

signaling pathway
blood pressure
high glucose
reactive oxygen species
diabetic rats
drug induced
cell proliferation
pi k akt
oxidative stress
endoplasmic reticulum stress
stress induced