EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution.

Julia Y MescheriakovaGijsbert P van NieropAnnemiek A van der EijkKarim L KreftRogier Q Hintzen

Published in: Neurology(R) neuroimmunology & neuroinflammation (2020)

In families with MS, the EBNA-1 IgG gradient being the highest in patients with MS, intermediate in their siblings, and lowest in biologically unrelated spouses indicates a genetic contribution to EBNA-1 IgG levels that is only partially explained by HLA-DRB1*1501 carriership.

Keyphrases

epstein barr virus
multiple sclerosis
diffuse large b cell lymphoma
mass spectrometry
genome wide
ms ms
white matter
copy number
dna methylation
intellectual disability