Muscle Weakness in Myositis: MicroRNA-Mediated Dystrophin Reduction in a Myositis Mouse Model and Human Muscle Biopsies.
Travis B KinderChristopher R HeierChristopher B TullyJack H Van der MuelenEric P HoffmanKanneboyina NagarajuAlyson A FiorilloPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
These data demonstrate that an acquired dystrophin deficiency may occur through NF-κB-regulated miRNAs in myositis, thereby suggesting a unifying theme in which muscle injury, inflammation, and weakness are perpetuated both in myositis and in DMD.
Keyphrases
- interstitial lung disease
- duchenne muscular dystrophy
- myasthenia gravis
- skeletal muscle
- mouse model
- muscular dystrophy
- systemic sclerosis
- oxidative stress
- endothelial cells
- signaling pathway
- rheumatoid arthritis
- transcription factor
- electronic health record
- big data
- inflammatory response
- machine learning
- immune response
- replacement therapy
- induced pluripotent stem cells
- pi k akt
- cell proliferation
- ultrasound guided