Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3.
Xiao-Shan ShiLing-Hong MengXin LiDun-Jia WangXing-Wang ZhouFeng-Yu DuBin-Gui WangXiao-Ming LiPublished in: Chemistry & biodiversity (2020)
The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 μg/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 μg/mL.
Keyphrases
- anti inflammatory
- ms ms
- high resolution
- escherichia coli
- mass spectrometry
- multiple sclerosis
- oxidative stress
- endothelial cells
- magnetic resonance
- systematic review
- candida albicans
- risk assessment
- silver nanoparticles
- machine learning
- emergency department
- high throughput
- computed tomography
- data analysis
- staphylococcus aureus
- solid state
- molecular dynamics
- electron microscopy