Azithromycin Mechanisms of Action in CRS Include Epithelial Barrier Restoration and Type 1 Inflammation Reduction.
Axel Eluid RenteriaFabiana C P ValeraAnastasios ManiakasDamien AdamAli Filali-MouhimManon RuffinLeandra Endam MfunaEmmanuelle BrochieroMartin Y DesrosiersPublished in: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (2023)
Restoration of healthy epithelial function may represent a major mode of action of azithromycin in CRS. In vitro models show enhanced epithelial repair, while in vivo transcriptomics shows downregulation of pathways type 1 inflammation accompanied by upregulation of DNA repair and cell-cycle pathways. The maximal effect in patients with high levels of type 1-enhanced inflammation suggests that azithromycin may represent a novel therapeutic option for surgery-unresponsive CRS patients.
Keyphrases
- cell cycle
- dna repair
- oxidative stress
- cell proliferation
- end stage renal disease
- dna damage
- newly diagnosed
- ejection fraction
- chronic kidney disease
- minimally invasive
- prognostic factors
- single cell
- blood pressure
- coronary artery bypass
- long non coding rna
- acute coronary syndrome
- resistance training
- atrial fibrillation
- surgical site infection