Opioid-like adverse effects of tianeptine in male rats and mice.

T R BairdH I AkbaraliW L DeweyH ElderM KangS A MarshM R PeaceJ L PoklisE J SantosS Stevens Negus

Published in: Psychopharmacology (2022)

Tianeptine presents as a MOR agonist with resistance to tolerance and dependence in our ICSS assay in rats, and it has lower abuse potential by this metric than many commonly abused opioids. Nonetheless, tianeptine produces MOR agonist-like acute adverse effects that include motor impairment, constipation, and respiratory depression.

Keyphrases

chronic pain
pain management
liver failure
depressive symptoms
respiratory failure
high throughput
high fat diet induced
drug induced
aortic dissection
irritable bowel syndrome
type diabetes
intensive care unit
hepatitis b virus
adipose tissue
intimate partner violence
insulin resistance
skeletal muscle