Prevalence of potential sports-associated risk factors in Swiss amyotrophic lateral sclerosis patients.
Nina Feddermann-DemontAstrid JungeKonrad P WeberMichael WellerJiří DvořákAlexander Andrea TarnutzerPublished in: Brain and behavior (2017)
History of head injuries was the only extrinsic risk factor associated with accelerated neurodegeneration in ALS. There was no evidence for extrinsic factors predisposing former football and ice hockey players to ALS. Our data therefore support the hypothesis that not increased physical activity per se, but other unknown environmental factors and/or genetic profile or lifestyle-promoting physical fitness increases ALS susceptibility.
Keyphrases
- amyotrophic lateral sclerosis
- physical activity
- risk factors
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- body mass index
- cardiovascular disease
- prognostic factors
- metabolic syndrome
- gene expression
- genome wide
- type diabetes
- electronic health record
- weight loss
- machine learning
- big data
- dna methylation
- risk assessment
- depressive symptoms