The effect of Vortioxetine on the NLRP3 pathway and microglial activity in the prefrontal cortex in an experimental model of depression.

Gülin Ozdamar Unal Duygu Kumbul Doğuç Kuyaş Hekimler Öztürk Gamze Erkılınç Feyza Dönmez Eltaf Doğan Kıran Ramazan Oğuz Yuceer

Published in: Immunopharmacology and immunotoxicology (2024)

According to these results, it may be considered that NLRP3 inflammasome-associated neuroinflammatory response and microglial activation may play a role in the etiopathogenesis of ELS.

Keyphrases

nlrp inflammasome
prefrontal cortex
lipopolysaccharide induced
inflammatory response
lps induced
neuropathic pain
major depressive disorder
depressive symptoms
sleep quality
spinal cord injury