Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy.
Rasmus Erik Johansson MortensenMorten Orebo HolmströmThomas Landkildehus LisleJane P HasselbyGro L WillemoeÖzcan MetInge Marie SvaneJulia JohansenDorte L NielsenInna M ChenMads Hald AndersenPublished in: Journal for immunotherapy of cancer (2023)
in patients without spontaneous responses. Taken together, our data suggest that combining TGF-β-based vaccination with ICI/radiotherapy will be beneficial for patients with PC.
Keyphrases
- end stage renal disease
- early stage
- transforming growth factor
- ejection fraction
- chronic kidney disease
- newly diagnosed
- locally advanced
- radiation therapy
- dna damage
- prognostic factors
- peritoneal dialysis
- electronic health record
- cell cycle
- epithelial mesenchymal transition
- cell proliferation
- patient reported outcomes
- big data
- signaling pathway
- data analysis