Fetal mitochondrial DNA in maternal plasma in surrogate pregnancies: Detection and topology.

Mary-Jane L MaSergey YakovenkoHaiqiang ZhangSuk Hang ChengValentina ApryshkoAlex ZhavoronkovPeiyong JiangK C Allen ChanRossa W K ChiuY M Dennis Lo

Published in: Prenatal diagnosis (2020)

Fetal mtDNA is present in maternal plasma, and consists mainly of linear molecules. Surrogate pregnancies represent a valuable clinical scenario for exploring the biology and potential clinical applications of circulating mtDNA, for example, for pregnancies conceived following mitochondrial replacement therapy.

Keyphrases

mitochondrial dna
pregnancy outcomes
copy number
gestational age
replacement therapy
birth weight
preterm birth
pregnant women
smoking cessation
oxidative stress
dna methylation
loop mediated isothermal amplification
risk assessment
physical activity
human health
weight gain