Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property.

Objectives : Malvidin, a dietary anthocyanin can be a potent drug for the treatment of neuronal toxicity. The investigation was aimed to study the antioxidant role of malvidin against aluminum chloride (AlCl 3 )-induced neurotoxicity in rats. Methods : To evaluate the neuroprotective role of malvidin, the rats were divided into four different groups: group I received saline, group II received AlCl 3 , and groups III and IV were administered with 100 and 200 mg/kg malvidin after AlCl 3 for 60 days. During the evaluation period, all the groups were subjected to a behavioral test. On the 61st day of the study, rat brains were removed and used for a neurochemical assay. Results : From the present study, malvidin ameliorated the effects of AlCl 3 on behavioral parameters. Biochemical investigation revealed that oral treatment of malvidin shows neuroprotective effects through regulation of antioxidant levels and neuroinflammation in the AlCl 3 -exposed rats. Conclusion : The results indicate that malvidin possesses antioxidant activity via acetylcholinesterase inhibition and regulation of oxidative stress in neuronal cells. Hence, malvidin could be a potential drug in correcting Alzheimer's disease.