Increased pulmonary serotonin transporter in patients with chronic obstructive pulmonary disease who developed pulmonary hypertension.

Armin Frille Michael RullmannGeorg-Alexander BeckerMarianne PattJulia LuthardtSolveig TiepoltHubert WirtzOsama SabriSwen HesseHans-Juergen Seyfarth

Published in: European journal of nuclear medicine and molecular imaging (2020)

By applying [11C]DASB and PET/CT, semiquantitative measures of SERT availability are demonstrated in the lung vasculature of patients with COPD and/or PH. COPD patients who developed PH show increased pulmonary [11C]DASB uptake compared to COPD patients without PH indicating an implication of pulmonary SERT in the development of PH in COPD patients.

Keyphrases

pulmonary hypertension
chronic obstructive pulmonary disease
end stage renal disease
pet ct
newly diagnosed
ejection fraction
lung function
chronic kidney disease
prognostic factors
computed tomography
patient reported outcomes
pulmonary arterial hypertension
coronary artery
air pollution