Photocontrolled Single-/Dual-Site Alternative Fluorescence Probes Distinguishing Detection of H2S/SO2 in Vivo.
Weijie ZhangFangjun HuoCaixia YinPublished in: Organic letters (2019)
Herein, a novel fluorescent probe by integrating 4-azide-1,8-naphthalic anhydride and spiropyran was obtained. NT-N3-SP was capable of specifically monitoring H2S by azide reduced. Upon irradiation by alternate ultraviolet and visible light, both the structure and emission of spiropyran moiety in NT-N3-SP can be reversibly tuned. Importantly, the alternation will be interrupted in the presence of SO2. Additionally, NT-N3-SP was successfully used for detection of H2S/SO2 in cells and mice.
Keyphrases
- fluorescent probe
- living cells
- visible light
- single molecule
- induced apoptosis
- loop mediated isothermal amplification
- real time pcr
- label free
- cell cycle arrest
- small molecule
- type diabetes
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- radiation therapy
- radiation induced
- fluorescence imaging
- nucleic acid
- sensitive detection