Different pathogenesis of glucose intolerance in two subtypes of primary aldosteronism: Aldosterone-producing adenoma and idiopathic hyperaldosteronism.
Mikiko Okazaki-HadaAyako MoriyaMototsugu NagaoShinichi OikawaIzumi FukudaHitoshi SugiharaPublished in: Journal of diabetes investigation (2020)
Insulin secretion impairment and insulin resistance play pathogenic roles for glucose intolerance in aldosterone-producing adenoma and idiopathic hyperaldosteronism, respectively. In addition, primary aldosteronism treatments can ameliorate glucose intolerance more effectively in patients without obesity and/or central obesity.
Keyphrases
- insulin resistance
- metabolic syndrome
- high fat diet induced
- type diabetes
- blood glucose
- weight loss
- adipose tissue
- end stage renal disease
- high fat diet
- ejection fraction
- skeletal muscle
- newly diagnosed
- weight gain
- polycystic ovary syndrome
- angiotensin ii
- prognostic factors
- patient reported outcomes
- glycemic control
- body mass index