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Tolerability and Efficacy of the Anticluster of Differentiation 47 Antibody Magrolimab Combined With Azacitidine in Patients With Previously Untreated AML: Phase Ib Results.

Naval G DaverParesh VyasSuman KambhampatiMonzr M Al MalkiRichard A LarsonAdam S AschGabriel MannisWanxing Chai-HoTiffany N TanakaTerrence J BradleyDeepa JeyakumarEunice S WangKendra SweetHagop M KantarjianGuillermo Garcia ManeroRami S KomrokjiGuan XingGiridharan RamsinghCamille RenardJoshua F ZeidnerDavid A Sallman
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
mutations, warranting further evaluation of magrolimab with azacitidine in AML. The phase III randomized ENHANCE-2 (ClinicalTrials.gov identifier: NCT04778397) and ENHANCE-3 (ClinicalTrials.gov identifier: NCT05079230) studies are recruiting frontline patients with AML.
Keyphrases
  • acute myeloid leukemia
  • phase iii
  • open label
  • double blind
  • placebo controlled
  • clinical trial
  • allogeneic hematopoietic stem cell transplantation
  • phase ii
  • study protocol
  • acute lymphoblastic leukemia