Terminal differentiation of keratinocytes was damaged in type 2 diabetic mice.
Takeshi TakayanagiHiroyuki HiraiYohei AsadaTakaaki YamadaSeiji HasegawaEisuke TomatsuYoshiteru MaedaYasumasa YoshinoIzumi HiratsukaSahoko Sekiguchi-UedaMegumi ShibataYusuke SeinoYoshihisa SugimuraHirohiko AkamatsuMitsuyasu ItohAtsushi SuzukiPublished in: Molecular biology reports (2022)
The terminal differentiation process was impaired in the diabetic skin, while keratinocyte proliferation was preserved. Damaged terminal differentiation of keratinocytes may contribute to impairment of the skin barrier function in diabetic dermatoses.
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