Virologic failure and all-cause mortality among older people living with HIV/AIDS in South China.
Qiuying ZhuJinghua HuangXiuling WuHuanhuan ChenZhiyong ShenHui XingYiming ShaoYuhua RuanXiangjun ZhangGuanghua LanPublished in: AIDS care (2022)
This retrospective cohort study investigated older people living with HIV/AIDS (PLWHA) characteristics, HIV care, and treatment outcomes among all cases between 1996 and 2019 in Guangxi, China. Secondary data were extracted from two national surveillance databases. Older (≥50 years old) and younger (18-49 years old) PLWHA were compared regarding demographic and behavioral characteristics, HIV care, virologic failure, and all-cause mortality. Older PLWHA accounted for 41.6% of all HIV cases (N = 144,952) between 1996 and 2019. The proportion of older cases increased from 10.4% to 64.8% for men and from 2.4% to 66.7% for women between 2002 and 2019. Heterosexual contact accounted for 96.0% of older adults. Moreover, older PLWHA had a lower median CD4 count at the HIV diagnosis (193 vs. 212 cells/μL, p < 0.0001) and were less likely to receive antiretroviral therapy (ART) than younger adults (72.1% vs. 86.1%, p < 0.001). The all-cause mortality risk of older PLWHA was 2.87 times of younger adults [adjusted hazard ratio (AHR) 2.87; 95% confidence interval (CI) 2.76-2.98]. In addition, older PLWHA reported an 18% increase in odds for virologic failure than younger adults (AOR 1.18; 95% CI 1.08-1.30). Therefore, enhanced HIV prevention and care are urgently needed in older people.
Keyphrases
- antiretroviral therapy
- hiv aids
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv infected patients
- community dwelling
- physical activity
- middle aged
- healthcare
- induced apoptosis
- quality improvement
- public health
- hepatitis c virus
- big data
- chronic pain
- mass spectrometry
- type diabetes
- cell proliferation
- polycystic ovary syndrome
- atomic force microscopy
- hiv testing
- combination therapy
- men who have sex with men
- electronic health record