Simple and Efficient Hydrogen Bond-Assisted Unit Exchange for Constructing Highly Soluble Covalent Organic Frameworks.

The majority of COFs synthesized using current methods exist as insoluble powders, which is unfavorable for processing and molding and greatly limits their practical applications. The syntheses of solution-processable or soluble COFs are challenging but hold immense promise and potential. Herein, for the first time, we have developed a simple and high-efficiency solvothermal-treated unit exchange approach to convert insoluble COF powders into smaller, highly soluble COFs via a hydrogen bond-assisted strategy. Due to the enhanced backbone-solvent hydrogen-bonding interactions between COFs and protic solvents and the effect of grain size reduction, the COFs after unit exchange can be easily dissolved in various protic solvents while remaining as insoluble powders in nonprotic solvents. The obtained soluble COFs exhibit remarkable fluorescence quenching upon detection of iodine in aqueous solution, with a detection limit as low as 75 nM, and can be fabricated into membranes for the efficient treatment of iodine-contaminated solutions.