CALR-mutated patients with low allele burden represent a specific subtype of essential thrombocythemia: A study on behalf of FIM and GBMHM.
Laura AubinRúben Vilas BoasRafael Daltro De OliveiraValoris Le BrunMarion DivouxJérôme ReyOlivier MansierJean-Christophe IanottoCédric PastoretAnne DesmaresAnne MuratiVéronique de MasSuzanne TavitianFrançois GirodonJuliette Soret DulphyNabih MaslahValérie Goncalves MonteiroFrançoise BoyerCorentin OrvainDana RantaÉmilie CayssialsLenaig Le ClechChristophe NicolCamille RottierTeresa Botin LopezBrice CastelPatrick RispalGuillaume BeziatCharles BescondKamel LaribiLina BenajibaValérie UgoEric LippertLaurane CottinDamien Luque PazPublished in: American journal of hematology (2024)
A low allele burden (i.e., <20%) of the CALR driver mutation is found in 10.8% of CALR-mutated MPNs, mostly in essential thrombocythemia, and correlates with a milder phenotype and a more indolent evolution compared to patients with an allele burden ≥20%.
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