Blood-brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs.

Erez HanaelShelly BaruchRotem Kalev AltmanOrit ChaiKira RapoportDana PeeryAlon FriedmanMerav H Shamir

Published in: Journal of veterinary internal medicine (2024)

Our findings demonstrate BBBD in dogs with IE and were supported by increased MMP9 activity and downregulation of astrocytic potassium channels and some TJ proteins. Blood brain barrier dysfunction may be a novel antiepileptic therapy target.

Keyphrases

blood brain barrier
cerebral ischemia
oxidative stress
cell proliferation
signaling pathway
transcription factor
bone marrow
cell therapy