Evolution of Antibiotic Resistance in Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Multi-Profile Hospital over 5 Years (2017-2021).
Beata MączyńskaMagdalena Frej-MądrzakJolanta SarowskaKrystyna WoronowiczIrena Choroszy-KrólAgnieszka Jama-KmiecikPublished in: Journal of clinical medicine (2023)
In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative Enterobacterales : Escherichia coli and Klebsiella pneumoniae , isolated from infections in a multi-profile hospital over five years (from 2017 to 2021). Among the practical outcomes of the evaluation of these data will be the possibility of determining changes in susceptibility to the antibiotics used in the hospital. In turn, this will help propose new therapeutic options, especially for empirical therapy that is necessary in severe infections. The analysis of the use of individual groups of antibiotics allowed for identification of the causes of the increasing resistance of Gram-negative bacilli. The highest number of infections whose etiological agent was K. pneumoniae ESBL(+) and E. coli ESBL(+) was observed in 2018. In the analyzed five-year period, the number of multi-resistant (MDR) K. pneumoniae strains increased successively, which seems to be related to the growing use, especially in the pandemic period, of broad-spectrum antibiotics, mainly penicillins with inhibitors, third-generation cephalosporins, and carbapenems.
Keyphrases
- klebsiella pneumoniae
- gram negative
- multidrug resistant
- escherichia coli
- healthcare
- acute care
- sars cov
- coronavirus disease
- adverse drug
- staphylococcus aureus
- emergency department
- physical activity
- stem cells
- skeletal muscle
- body mass index
- pseudomonas aeruginosa
- weight loss
- electronic health record
- respiratory tract
- type diabetes
- biofilm formation
- weight gain
- glycemic control
- early onset
- replacement therapy