This review discusses current data on CNS lesions in infections with the new coronavirus that causes COVID-19. The pathogenetic mechanisms leading to infection of the brain and spinal cord are presented. Published studies and meta-analyses published by autumn 2020 are assessed. The authors present results from their own clinical observations of various types of CNS infection in COVID-19 virus disease. Particular attention is paid to certain common forms of CNS lesion such as encephalitis, cerebrovascular pathology, and headache. A form of acute hemorrhagic necrotic encephalopathy is identified, which is a quite rare but fatal pathology comorbid with COVID-19. A description of our own clinical observation of acute necrotic encephalopathy is presented. The importance of further studies of the effects of the coronavirus on the CNS and possible approaches to treatment and rehabilitation of this category of patients is emphasized.
Keyphrases
- sars cov
- coronavirus disease
- meta analyses
- respiratory syndrome coronavirus
- blood brain barrier
- spinal cord
- liver failure
- end stage renal disease
- systematic review
- respiratory failure
- chronic kidney disease
- early onset
- newly diagnosed
- electronic health record
- white matter
- patient reported outcomes
- machine learning
- neuropathic pain
- cerebral ischemia
- hepatitis b virus