pRB immunostaining in the differential diagnosis between pleomorphic xanthoastrocytoma and glioblastoma with giant cells.

Valeria Barresi Michele SimboloChiara CiaparroneSerena PedronAndrea Mafficini Aldo Scarpa

Published in: Histopathology (2022)

This study shows for the first time that loss of pRB immunostaining is sensitive and specific for distinguishing GBM with GCs from PXA in routine practice. Thus, it could complement an immunohistochemical panel that includes BRAF and p53 immunostainings for the differential diagnosis.

Keyphrases

induced apoptosis
healthcare
primary care
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
cell death
cell proliferation
rare case