"Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction".
Federica PapaccioBlanca García-MicoFrancisco Gimeno-ValienteManuel Cabeza-SeguraValentina GambardellaMaría Fernanda Gutiérrez-BravoClara Alfaro-CervellóCarolina Martinez-CiarpagliniPilar Rentero-GarridoSheila Zúñiga-TrejosJuan Antonio Carbonell-AsinsTania FleitasSusana RosellóMarisol HuertaManuel M Sánchez Del PinoLuís SabaterDesamparados RodaNoelia TarazonaAndres CervantesJosefa CastilloPublished in: Journal of experimental & clinical cancer research : CR (2023)
Our strategy of integrating PDOs drug sensitivity with SWATH-mass spectrometry and RNA-seq allowed us to identify different baseline proteins and gene expression profiles with the potential to predict treatment response/resistance and to help in the development of effective and personalized cancer therapeutics.
Keyphrases
- rna seq
- single cell
- mass spectrometry
- papillary thyroid
- adverse drug
- liquid chromatography
- squamous cell
- small molecule
- genome wide
- copy number
- high resolution
- drug induced
- squamous cell carcinoma
- gene expression
- capillary electrophoresis
- high performance liquid chromatography
- dna methylation
- lymph node metastasis
- risk assessment
- climate change
- childhood cancer
- simultaneous determination