Urinary fluorescent metabolite O-aminohippuric acid is a useful biomarker for lung cancer detection.

Kazuhito FunaiKatsu HonzawaMasako SuzukiShigeru MomikiKatsuyuki AsaiNorio KasamatsuAkikazu KawaseTomomi ShinkeHiroyuki OkadaSadahiko NishizawaHisayoshi Takamoto

Published in: Metabolomics : Official journal of the Metabolomic Society (2020)

We identified a fluorescent urinary metabolite that can predict lung cancer. OAH exceeds the AUC (0.817) of lung cancer detection by AminoIndex® cancer screening, can be analyzed non-invasively without additional sample processing, and may be a valuable addition to existing lung cancer prediction models.

Keyphrases

label free
quantum dots
living cells
squamous cell carcinoma
real time pcr
single molecule
lymph node metastasis