DOAC plasma concentration upon hospital admission in a cohort of trauma patients. An observational real-life study.
Carolin RuoffHerbert SchöchlGerhard FritschWolfgang G VoelckelJohannes ZipperleJohannes GratzFelix Carl Fabian SchmittDaniel OberladstaetterPublished in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2023)
The current study revealed that patients on dabigatran and rivaroxaban were prone to higher DOAC plasma levels upon hospital admission in comparison with apixaban and edoxaban. DOAC plasma level measurement in trauma patients might be warranted due to unpredictively low or high plasma concentrations. However, the clinical impact of altered plasma levels on both, bleeding and thromboembolic events, remains to be determined by future studies.