Calcitonin receptor antibody validation and expression in the rodent brain.
Erica R HendrikseTayla A ReesZoe TasmaChristelle Le FollThomas A LutzAndrew SiowPeter J WookeyChristopher S WalkerDebbie L HayPublished in: Cephalalgia : an international journal of headache (2022)
Anti-calcitonin receptor antibodies require comprehensive profiling to ensure confidence in the detection of calcitonin receptor. Using a validated antibody, calcitonin receptor-like immunoreactivity was detected in several brain regions relevant to migraine. Further research is needed to understand the functional consequences of calcitonin receptor expression for calcitonin gene-related peptide or amylin physiology and pathophysiology.