Mutant Huntingtin Drives Development of an Advantageous Brain Early in Life: Evidence in Support of Antagonistic Pleiotropy.

Mohit Neema Jordan L SchultzDouglas R LangbehnAmy L ConradEric A EppingVincent A MagnottaPeggy C Nopoulos

Published in: Annals of neurology (2024)

Mutant HTT may drive the development of a larger than normal brain that subserves superior early-life function. These findings support the antagonistic pleiotropy theory of HTT in HD, where this gene drives early advantage followed by accelerated aging processes. ANN NEUROL 2024.

Keyphrases

early life
resting state
white matter
functional connectivity
cerebral ischemia
wild type
gene expression
transcription factor
blood brain barrier
subarachnoid hemorrhage