PIK3CA-related overgrowth spectrum: animal model and drug discovery.

Published in: Comptes rendus biologies (2021)

This review recapitulates the recent knowledge accumulation on overgrowth syndrome related to gain of function of the phosphoinositide3 kinase (PI3K)-alpha. These disorders, known as PIK3CA related overgrowth syndromes (PROS) are caused by somatic PIK3CA mutation occurring during embryogenesis. We summarize here the currently available animal models and new treatments undergoing development.

Keyphrases

drug discovery
protein kinase
gene expression
dna methylation
tyrosine kinase
genome wide