Disruption of nuclear speckles reduces chromatin interactions in active compartments.

Shibin HuPin LvZixiang YanBo Wen

Published in: Epigenetics & chromatin (2019)

We show that disruption of NSs by Srrm2 knockdown causes a global decrease in chromatin interactions in active compartments, indicating critical functions of NSs in the organization of the 3D genome.

Keyphrases

genome wide
dna damage
gene expression
transcription factor