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Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review.

Mohamed S MostafaIbrahim Ali M RadiniNaglaa M Abd El-RahmanRizk E Khidre
Published in: Molecules (Basel, Switzerland) (2024)
This review article examines the synthetic pathways for triazolothiadiazine derivatives, such as triazolo[3,4- b ]thiadiazines, triazolo[5,1- b ]thiadiazines, and triazolo[4,3- c ]thiadiazines, originating from triazole derivatives, thiadiazine derivatives, or thiocarbohydrazide. The triazolothiadiazine derivatives exhibit several biological actions, including antibacterial, anticancer, antiviral, antiproliferative, analgesic, anti-inflammatory, and antioxidant properties. The review article aims to assist researchers in creating new biologically active compounds for designing target-oriented triazolothiadiazine-based medicines to treat multifunctional disorders.
Keyphrases
  • anti inflammatory
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  • oxidative stress
  • drug delivery
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  • spinal cord