DNA Methylation and Telomeres-Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging.
Arkadiusz GrzeczkaSzymon GraczykPaweł KordowitzkiPublished in: International journal of molecular sciences (2023)
Atrial fibrillation (AF) is the most common arrhythmia in humans. AF is characterized by irregular and increased atrial muscle activation. This high-frequency activation obliterates the synchronous work of the atria and ventricles, reducing myocardial performance, which can lead to severe heart failure or stroke. The risk of developing atrial fibrillation depends largely on the patient's history. Cardiovascular diseases are considered aging-related pathologies; therefore, deciphering the role of telomeres and DNA methylation (mDNA), two hallmarks of aging, is likely to contribute to a better understanding and prophylaxis of AF. In honor of Prof. Elizabeth Blackburn's 75th birthday, we dedicate this review to the discovery of telomeres and her contribution to research on aging.
Keyphrases
- atrial fibrillation
- catheter ablation
- dna methylation
- high frequency
- heart failure
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- left ventricular
- transcranial magnetic stimulation
- cardiovascular disease
- gene expression
- percutaneous coronary intervention
- genome wide
- risk assessment
- small molecule
- skeletal muscle
- case report
- type diabetes
- coronary artery disease
- drug induced