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Applications of Microfluidic Devices in the Diagnosis and Treatment of Cancer: A Review Study.

Negah MahhengamAli Fahem Ghetran KhazaaliSurendar AravindhanAngelina Olegovna ZekiyLyubov MelnikovaHomayoon Siahmansouri
Published in: Critical reviews in analytical chemistry (2021)
Many cancer-related deaths are reported annually due to a lack of appropriate diagnosis and treatment strategies. Microfluidic technology, as new creativity has a great impact on automation and miniaturization via handling a small volume of materials and samples (in microliter to femtoliter range) to set up the system. Microfluidic devices not only detect various cancer-diagnostic factors from biological fluids but also can produce proper nanoparticles for drug delivery. With the contribution of microfluidics; multiple treatments for cancer such as chemotherapy, radiation therapy, and gene delivery can be implemented and studied. Hence, Microfluidics can be worth for the cancer field because of its high Throughput, high sensitivity, less material use, and low expense. In this review study, we intend to look at positive microfluidics prospects, features, benefits, and clinical applications.
Keyphrases
  • high throughput
  • papillary thyroid
  • radiation therapy
  • squamous cell
  • drug delivery
  • single cell
  • squamous cell carcinoma
  • circulating tumor cells
  • locally advanced
  • radiation induced
  • label free