Gut microbiome and plasma metabolome changes in rats after oral gavage of nanoparticles: sensitive indicators of possible adverse health effects.

Robert LandsiedelDaniela HahnRainer OssigSabrina RitzLydia SauerRoland BuesenSascha RehmWendel WohllebenSibylle GroetersVolker StraussSaskia SperberHaleluya WamiUlrich DobrindtKarola PriorDag HarmsenBennard van RavenzwaayJuergen Schnekenburger

Published in: Particle and fibre toxicology (2022)

The combined profiling of intestinal microbiome and plasma metabolome may serve as an early and sensitive indicator of gut microbiome changes induced by orally administered nanoparticles; this will help to recognize potential adverse effects of these changes to the host.

Keyphrases

single cell
adverse drug
risk assessment