Positively selected variants in functionally important regions of TLR7 in Alouatta guariba clamitans with yellow fever virus exposure in Northern Argentina.
Nicole S TorosinTimothy H WebsterHernán ArgibayCandelaria Sanchez FernandezHebe FerreyraMarcela UhartIlaria AgostiniLeslie A KnappPublished in: American journal of physical anthropology (2020)
Our results did not indicate that surviving howler monkey spossess advantageous genetic variants at greater frequency than those alive before the YFV outbreak. However, the positively selected unique coding differences in A. guariba clamitans are in the region important in pathogen detection which may affect YFV resistance. Morework is necessary to fully explore this hypothesis.