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Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents.

Johanna TemplMichael Schnürch
Published in: The Journal of organic chemistry (2022)
We describe the use of phenyl trimethylammonium iodide (PhMe 3 NI) as an alternative methylating agent for introducing a CH 3 group in α-position to a carbonyl group. Compared to conventional methylating agents, quaternary ammonium salts have the advantages of being nonvolatile, noncancerogenic, and easy-to-handle solids. This regioselective method is characterized by ease of operational setup, use of anisole as green solvent, and yields up to 85%.
Keyphrases
  • ionic liquid
  • room temperature
  • dna methylation
  • genome wide
  • gene expression
  • metal organic framework