Comprehensive screening for drugs that modify radiation-induced immune responses.
Masayuki OkumuraJunyan DuShun-Ichiro KageyamaRiu YamashitaYumi HakozakiAtsushi MotegiHidehiro HojoMasaki NakamuraYasuhiro HiranoYusuke OkumaHitomi Sumiyoshi OkumaKatsuya TsuchiharaTetsuo AkimotoPublished in: British journal of cancer (2022)
Our study provides an encyclopedic catalogue of clinically approved drugs based on their effect on RIIR. In ICIs combined radiotherapy, activation of STING-IFN may improve the therapeutic effect and our result could form a biological basis for further clinical trials combining radiotherapy with ICIs.