Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases.

Liesel M FitzGeraldS ZhaoA LeonardsonM S GeybelsS KolbD W LinJ L WrightRosalind A EelesZ Kote-JaraiK GovindasamiG G GilesM C SoutheyJ SchleutkerT L TammelaCsilla SipekyK L PenneyM J StampferH GronbergF WiklundP StattinJ HugossonD M KaryadiE A OstranderZ FengJ L Stanford

Published in: Prostate cancer and prostatic diseases (2018)

This meta-analysis confirms the association of three genetic variants with risk of PCSM, providing further evidence that genetic background plays a role in PCa-specific survival. While these variants alone are not sufficient as prognostic biomarkers, these results may provide insights into the biological pathways modulating tumour aggressiveness.

Keyphrases

prostate cancer
copy number
radical prostatectomy
systematic review
signaling pathway
cell proliferation
genome wide
meta analyses
risk factors
dna repair
gene expression
coronary artery disease
dna methylation
free survival
dna damage
oxidative stress