Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects.

Areti-Maria VasilogianniZubida M Al-MajdoubBrahim AchourSheila Annie PetersAmin Rostami-HodjeganJill Barber

Published in: British journal of clinical pharmacology (2021)

This study highlights impaired drug metabolism, perturbed drug transport and altered abundance of cancer markers in CRLM, demonstrating the importance of population-specific abundance data in PBPK models for cancer.

Keyphrases

papillary thyroid
squamous cell
adverse drug
mass spectrometry
high resolution
antibiotic resistance genes
drug induced
squamous cell carcinoma
deep learning