Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study.
Alev YilmazAlberto Caldas AfonsoIpek AkilBagdagul AksuHarika AlpayBahriye AtmisOzlem AydogAysun Karabay BayazıtMeral Torun BayramIlmay BilgeIpek Kaplan BulutBahar BuyukkaragozElif ComakBelde Kasap DemirNida DincelOsman DonmezMehmet Akif DurmusHasan DursunRuhan DusunselAli DuzovaPelin ErtanAsuman GedikbasiNilufer GoknarSercin GuvenDuygu HacihamdiogluAugustina JankauskieneMukaddes KalyoncuSalih KavukcuBahriye Uzun KenanNuran KucukBahar KuralMieczysław LitwinGiovanni MontiniWilliam MorelloAhmet NayirLukasz ObryckiBeyhan OmerEbru Misirli OzdemirNese OzkayinDusan ParipovicCemile PehlivanogluSeha SaygiliSusanne SchaeferFerah SonmezYilmaz TabelNesrin TasMehmet TasdemirAna TeixeiraDemet TekcanSebahat TulparOzde Nisa TurkkanBerfin UysalMetin UysalolDaiva VaiciunieneSevgi YavuzSibel YelTarik YildirimZeynep Yuruk YildirimNurdan YildizSelcuk YukselEray YurtsevenFranz SchaeferRezan TopalogluPublished in: Pediatric nephrology (Berlin, Germany) (2022)
Urine HSP70 is a novel non-invasive marker of UTI that improves the diagnostic accuracy of conventional urinalysis. We estimate that rapid urine HSP70 screening could spare empiric antibiotic administration in up to 80% of children with suspected UTI. A higher resolution version of the Graphical abstract is available as Supplementary information.