Inflammatory panel cytokines are elevated in the neocortex of late-stage Alzheimer's disease but not Lewy body dementias.
Yuek Ling ChaiJasinda H LeeJoyce R ChongClive BallardPaul T FrancisBrian K KennedyThiruma V ArumugamChristopher P ChenDag AarslandMitchell Kim Peng LaiPublished in: Journal of neuroinflammation (2023)
We found IL-1α, IFN-γ, GM-CSF and IL-13 to be elevated in the mid-temporal cortex of AD patients. In contrast, none of the measured cytokines were significantly altered in either DLB or PDD. Similar cytokine changes were observed in two other neocortical areas of AD patients. Furthermore, increases of IL-1α, IFN-γ, GM-CSF, IL-10 and IL-13 associated with moderate-to-severe neurofibrillary tangle burden, but not with neuritic plaques or Lewy bodies. Our findings of elevated neocortical pro- and anti-inflammatory cytokines in AD, but not in DLB or PDD, suggest that neuroinflammatory responses are strongly linked to neurofibrillary tangle burden, which is higher in AD compared to LBD. In conclusion, neuroinflammation may not play a prominent role in the pathophysiology of late-stage LBD.
Keyphrases
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- parkinson disease
- magnetic resonance
- oxidative stress
- immune response
- traumatic brain injury
- prognostic factors
- magnetic resonance imaging
- cognitive impairment
- functional connectivity
- cognitive decline
- drug induced
- early onset
- mild cognitive impairment
- patient reported