Lack of vitamin D signalling shifts skeletal muscles towards oxidative metabolism.

Anamica DasNeha JawlaVaidehee MeenaSuchitra D GopinathGopalakrishnan Aneeshkumar Arimbasseri

Published in: Journal of cachexia, sarcopenia and muscle (2023)

mice. This study reveals that when mice are subjected to a lard-based HFD, VDR signalling is essential for maintaining insulin levels in pancreatic islets. Our data show a critical role of VDR in muscle metabolic flexibility and pancreatic insulin response.

Keyphrases

type diabetes
high fat diet induced
glycemic control
high fat diet
skeletal muscle
big data
insulin resistance
wild type
adipose tissue
weight loss