CYP2C19⁎2 Polymorphism in Chilean Patients with In-Stent Restenosis Development and Controls.
Jenny RuedlingerYalena PradoTomás ZambranoNicolás SaavedraBraulio BobadillaMarcelo PotthoffLuis PérezFernando LanasLuis A SalazarPublished in: BioMed research international (2017)
Clopidogrel is an antiplatelet drug especially used in patients undergoing percutaneous coronary interventions (PCI). Polymorphisms within CYP2C19 can result in important interindividual variations regarding therapeutic efficacy. Therefore, we aimed to evaluate the impact of the CYP2C19⁎2 variant (rs4244285) on in-stent restenosis occurrence in Chilean patients who underwent PCI and received clopidogrel. A total of 77 cases with stenosis >50% in the angioplasty site (62.75 ± 9.8 years, 80.5% males) and 86 controls (65.45 ± 9.8 years, 72.1% males) were studied. The polymorphism was genotyped using TaqMan® Drug Metabolism Genotyping Assays. Overall, CYP2C19⁎2 allele frequency was 8.3%. Diabetes, chronic lesions, and bare metal stents (BMS) were observed more often in cases than in controls (p = 0.05, p = 0.04, and p = 0.02, resp.). Genotypic frequencies did not differ significantly between the groups (p = 0.15). Nonetheless, the mutated allele was observed in a greater proportion in patients without in-stent restenosis (p = 0.055). There was no significant association between the rs4244285 variant and the occurrence of in-stent restenosis after PCI (OR = 0.44; 95% CI: 0.19 to 1.04; p = 0.06). In summary, no association was identified between the CYP2C19⁎2 variant and the development of coronary in-stent restenosis.
Keyphrases
- coronary artery disease
- acute coronary syndrome
- percutaneous coronary intervention
- end stage renal disease
- antiplatelet therapy
- patients undergoing
- ejection fraction
- chronic kidney disease
- newly diagnosed
- acute myocardial infarction
- risk assessment
- type diabetes
- cardiovascular disease
- st segment elevation myocardial infarction
- peritoneal dialysis
- minimally invasive
- gene expression
- high throughput
- aortic stenosis
- physical activity
- st elevation myocardial infarction
- coronary artery bypass grafting
- adipose tissue
- emergency department
- metabolic syndrome
- left ventricular
- genome wide
- ultrasound guided
- weight loss
- insulin resistance
- electronic health record
- single cell
- real time pcr