Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study.

Katie A WitkiewitzAdam D WilsonMatthew R PearsonKevin A HallgrenDaniel E FalkRaye Z LittenHenry R KranzlerKarl F MannDeborah S HasinStephanie S O'MalleyRaymond K Anton

Published in: Alcoholism, clinical and experimental research (2017)

The results show stability of no heavy drinking as an outcome within the first 4 months of treatment and that the >3/>4 drink cutoff may mask substantial reductions in alcohol consumption among some patients. Future studies should explore the clinical utility of reduction end points.

Keyphrases

alcohol consumption
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
patient reported outcomes
patient reported
case control
combination therapy