Cutaneous iontophoresis of vasoactive medications in patients with scleroderma-associated pulmonary arterial hypertension.
Sami Al AbdiAllaa AlmoushrefTawfeq NaalCelia A MelilloKulwant S AulakMostafa K AhmedSoumya ChatterjeeKristin B HighlandRaed A DweikAdriano R TonelliPublished in: Microcirculation (New York, N.Y. : 1994) (2021)
Patients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests, presumably due to a peripheral reduction in prostacyclin receptor expression and nitric oxide bioavailability.