ZEB1 is Regulated by K811 Acetylation to Promote Stability, NuRD Complex Interactions, EMT, and NSCLC Metastasis.

Mabel Perez-Oquendo Roxsan Manshouri Yanhua Tian Jared F Fradette B Leticia Rodriguez Samrat T Kundu Don L Gibbons

Published in: Molecular cancer research : MCR (2023)

The molecular mechanisms by which ZEB1 is regulated by K811 acetylation to promote protein stability, NuRD complex and promoter interactions, and function are relevant to the development of treatment strategies to prevent and treat metastasis in patients with NSCLC.

Keyphrases

epithelial mesenchymal transition
small cell lung cancer
advanced non small cell lung cancer
long non coding rna
histone deacetylase
dna methylation
gene expression
transcription factor
signaling pathway
brain metastases
protein protein
binding protein