The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase-mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis.

Jingxia CuiShuli ManNina CuiLi YangQianbei GuoLong MaWenyuan Gao

Published in: Cell proliferation (2018)

Formosanin C and PVII showed a synergistic antitumour effect on lung cancer cells. The findings would provide the foundation for the use of combination drugs in the future.

Keyphrases

cell death
endoplasmic reticulum stress
induced apoptosis
oxidative stress
cell cycle arrest
signaling pathway
cancer therapy
current status
cell proliferation
pi k akt