Melatonin decreases plasma TNF-α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high-fat diet.
Rodrigo Martins Dos SantosThaís Verônica Saori TsosuraBianca Elvira BelardiAntônio Hernandes Chaves-NetoFernando Yamamoto ChibaMaria Sara de Lima Coutinho MatteraGestter Willian Lattari TessarinLara Teschi BravoLuciano Tavares Angelo CintraDóris Hissako MatsushitaPublished in: International endodontic journal (2022)
Apical periodontitis and HFD promoted IR, and the association of AP with diet promoted IR exacerbation; this resistance might have been caused by an increase in TNF-α. AP promoted more intense changes in lipid oxidative damage than in protein oxidative damage. In non-enzymatic antioxidant defence, it was observed that both AP and HFD and their association promoted a decrease in GSH levels. Overall, ME treatment reversed changes such as oxidative stress and IR.
Keyphrases
- high fat diet
- oxidative stress
- adipose tissue
- insulin resistance
- transcription factor
- rheumatoid arthritis
- anti inflammatory
- dna damage
- physical activity
- ischemia reperfusion injury
- diabetic rats
- metabolic syndrome
- weight loss
- skeletal muscle
- induced apoptosis
- combination therapy
- protein protein
- amino acid
- binding protein
- nitric oxide
- signaling pathway
- replacement therapy